Genomic data in the All of Us Research Program.

ABSTRACT: Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for the field of human genetics^1-4. The All of Us Research Program is a longitudinal cohort study aiming to enrol a diverse group of at least one million individuals across the USA to accelerate biomedical research and improve human health^5,6. Here we describe the programme's genomics data release of 245,388 clinical-grade genome sequences. This resource is unique in its diversity as 77% of participants are from communities that are historically under-represented in biomedical research and 46% are individuals from under-represented racial and ethnic minorities. All of Us identified more than 1 billion genetic variants, including more than 275 million previousl

SUBMITTER: All of Us Research Program Genomics Investigators 

PROVIDER: S-EPMC10937371 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature