The Identification of Enteric Fever-Specific Antigens for Population-Based Serosurveillance.

ABSTRACT:

Background

Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, is a major public health problem in low- and middle-income countries. Moderate sensitivity and scalability of current methods likely underestimate enteric fever burden. Determining the serological responses to organism-specific antigens may improve incidence measures.

Methods

Plasma samples were collected from blood culture-confirmed enteric fever patients, blood culture-negative febrile patients over the course of 3 months, and afebrile community controls. A panel of 17 Salmonella Typhi and Paratyphi A antigens was purified and used to determine antigen-specific antibody responses by indirect ELISAs.

Results

The antigen-specific longitudinal antibody responses were comparable betw

SUBMITTER: Mylona E 

PROVIDER: S-EPMC10938218 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature