Autoantibodies to ACE2 and immune molecules are associated with COVID-19 disease severity.

ABSTRACT:

Background

Increased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease manifestations. The mechanisms of this variable long-term immune activation are poorly defined. One feature of this increased inflammation is elevated levels of proinflammatory cytokines and chemokines. Autoantibodies targeting immune factors such as cytokines, as well as the viral host cell receptor, angiotensin-converting enzyme 2 (ACE2), have been observed after SARS-CoV-2 infection. Autoantibodies to immune factors and ACE2 could interfere with normal immune regulation and lead to increased inflammation, severe COVID-19, and long-term complications.

Methods

Here, we deeply profiled the features of ACE2, cytokine, and chemokine auto

SUBMITTER: Geanes ES 

PROVIDER: S-EPMC10943194 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature