Tumor-infiltrating CD8⁺ sub-populations in primary and recurrent glioblastoma: An in-silico study.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) remains an incurable primary brain tumor. CD8⁺ tumor-infiltrating lymphocytes (TILs) can target malignant cells; however, their anti-tumoral immune responses mostly do not lead to GBM rejection in GBM patients. We profiled the sub-populations of tumor-infiltrating CD8⁺ T-cells, i.e., naïve, cytotoxic, and exhausted cells, in primary and recurrent GBM tissues and provided a blueprint for future precision-based GBM immunotherapy.

Method

We re-analyzed the raw data of single-cell RNA sequencing on the cells residing in the GBM microenvironment and leveraged tumor bulk RNA analyses to study the significance of CD8⁺ TILs sub-populations in primary and recurrent GBM. We investigated cell-cell interaction bet

SUBMITTER: Abdoli Shadbad M 

PROVIDER: S-EPMC10943382 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature