Mycobacterium tuberculosis Rv2617c is involved in stress response and phage infection resistance.

ABSTRACT: Mycobacterium tuberculosis (M. tuberculosis) is the pathogen of human tuberculosis (TB). Resistance to numerous in vivo stresses, including oxidative stress, is determinant for M. tuberculosis intracellular survival, and understanding associated mechanisms is crucial for developing new therapeutic strategies. M. tuberculosis Rv2617c has been associated with oxidative stress response when interacting with other proteins in M. tuberculosis; however, its functional promiscuity and underlying molecular mechanisms remain elusive. In this study, we investigated the phenotypic changes of Mycobacterium smegmatis (M. smegmatis) expressing Rv2617c (Ms_Rv2617c) and its behavior in the presence of various in vitro stresses and phage infect

SUBMITTER: Moukendza Koundi L 

PROVIDER: S-EPMC10943396 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature