The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent.

ABSTRACT:

Background

How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized.

Methods

We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TME, PyMT AT-3 mammary tumors and B16F1 melanoma.

Results

We show that whereas firmly adherent platelets continuously line tumor vessels of both AT-3 and B16F1 tumors, abundant extravascular stromal clusters of platelets from thrombopoietin-independent origin were present only in AT-3 mammary tumors. We further show that platelets influence the angiogenic and inflammatory profiles of AT-3 and B16F1 tumors, though with very different outcomes according to tumor type. Whereas thrombocytopenia increased bleeding in both tumor types, it

SUBMITTER: Le Chapelain O 

PROVIDER: S-EPMC10944607 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature