Predicting postoperative lung function using ventilation SPECT/CT in patients with lung cancer.

ABSTRACT:

Background

Single-photon emission computed tomography/computed tomography (SPECT/CT) has the advantage of assessing regional lung function. We aimed to investigate the potential of ventilation (SPECT/CT) for predicting postoperative lung function in patients with lung cancer.

Methods

This retrospective study included consecutive patients with lung cancer who underwent lobectomy, preoperative ventilation, and perfusion SPECT/CT between January 2020 and December 2021. The percentage of predicted postoperative forced expiratory volume in 1 s (ppoFEV₁%) and the percentage of predicted postoperative diffusion capacity of the lung for carbon monoxide (ppoDL_CO%) were calculated from the % counts of each scan based on anatomical segments for lobar function. Correlation tests were performed between the predicted lung function values and actual ppoFEV₁% and ppoDL_CO%.

Results

Among the 47 patients, 29 men and 18 women aged 67.5±9.6 years were included. Moreover, 46 ventilation and 41 perfusion SPECT/CT scans were obtained. The pulmonary function on ventilation SPECT/CT strongly correlated with perfusion SPECT/CT (correlation coefficient r=0.939 for ppoFEV₁%, P<0.001; r=0.938 for ppoDL_CO%, P<0.001). Both ppoFEV₁% and ppoDL_CO% values obtained from the ventilation and perfusion scans strongly correlated with postoperative FEV₁% and DL_CO% (correlation coefficient, r=0.774 and r=0.768 for ventilation; r=0.795 and r=0.751 for perfusion, each P<0.001).

Conclusions

Ventilation SPECT/CT was comparable to perfusion SPECT/CT in predicting postoperative lung function.

SUBMITTER: Jeong YH 

PROVIDER: S-EPMC10944722 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature