Dataset Information

Associations between symptoms and functional capacity in patients after COVID-19 infection and community controls.

ABSTRACT:

Background

Post-acute sequelae of COVID-19 (PASC or 'long COVID') reflect ongoing symptoms, but these are non-specific and common in the wider community. Few reports of PASC have been compared with a control group.

Aims

To compare symptoms and objective impairment of functional capacity in patients with previous COVID-19 infection with uninfected community controls.

Methods

In this community-based, cross-sectional study of functional capacity, 562 patients from Western Melbourne who had recovered from COVID-19 infections in 2021 and 2022 were compared with controls from the same community and tested for functional capacity pre-COVID-19. Functional impairment (<85% of the predicted response) was assessed using the Duke Activity Status Index (DASI) and 6-min walk distance (6MWD) test. A subgroup underwent cardiopulmonary exercise testing before and after exercise training.

Results

Of 562 respondents (age 54 ± 12 years, 69% women), 389 were symptomatic. Functional impairment (<85% predicted metabolic equivalent of tasks) was documented by DASI in 149 participants (27%), and abnormal 6MWD (<85% predicted) was observed in 14% of the symptomatic participants. Despite fewer risk factors and younger age, patients with COVID-19 had lower functional capacity by 6MWD (P < 0.001) and more depression (P < 0.001) than controls. In a pilot group of seven participants (age 58 ± 12 years, two women, VO₂ 18.9 ± 5.7 mL/kg/min), repeat testing after exercise training showed a 20% increase in peak workload.

Conclusions

Although most participants (69%) had symptoms consistent with long COVID, significant subjective functional impairment was documented in 27% and objective functional impairment in 14%. An exercise training programme might be beneficial for appropriately selected patients.

SUBMITTER: Huynh Q

PROVIDER: S-EPMC10947235 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Associations between symptoms and functional capacity in patients after COVID-19 infection and community controls.

Huynh Quan Q Wexler Noah N Smith Joel J Wright Leah L Ho Felicia F Allwood Richard R Sata Yusuke Y Manca Stefano S Howden Erin E Marwick Thomas H TH

Internal medicine journal 20230725 9

<h4>Background</h4>Post-acute sequelae of COVID-19 (PASC or 'long COVID') reflect ongoing symptoms, but these are non-specific and common in the wider community. Few reports of PASC have been compared with a control group.<h4>Aims</h4>To compare symptoms and objective impairment of functional capacity in patients with previous COVID-19 infection with uninfected community controls.<h4>Methods</h4>In this community-based, cross-sectional study of functional capacity, 562 patients from Western Melb ...[more]

PMID: 37490523

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Dataset Information

Associations between symptoms and functional capacity in patients after COVID-19 infection and community controls.

Background

Aims

Methods

Results

Conclusions

Publications

Associations between symptoms and functional capacity in patients after COVID-19 infection and community controls.

Similar Datasets

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