Mesothelin expression in gynecologic carcinosarcoma: clinicopathological significance and correlation with HER2 expression.

ABSTRACT:

Objective

This study aimed to evaluate mesothelin (MSLN) expression and determine its clinical significance and correlation with human epidermal growth factor receptor 2 (HER2) expression in gynecological carcinosarcoma.

Methods

We retrospectively evaluated patients with uterine carcinosarcoma (UCS) and ovarian carcinosarcoma (OCS) who underwent surgery between 1997 and 2019. Immunohistochemical staining of formalin-fixed, paraffin-embedded specimens for MSLN (clone SP74) and HER2 (clone 4A5) was also performed. MSLN was scored using the H-score and 4-tired scoring system (0-3+). MSLN positivity was defined as any positive cell at any intensity, while high MSLN expression was defined as an intensity of ≥2+ in ≥30% of tumor cells. HER2 expression was scored according to modif

SUBMITTER: Kitadai R 

PROVIDER: S-EPMC10948979 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature