Red blood cell transfusion in neurocritical patients: a systematic review and meta-analysis.

ABSTRACT:

Background

Anemia can lead to secondary brain damage by reducing arterial oxygen content and brain oxygen supply. Patients with acute brain injury have impaired self-regulation. Brain hypoxia may also occur even in mild anemia. Red blood cell (RBC) transfusion is associated with increased postoperative complications, poor neurological recovery, and mortality in critically ill neurologic patients. Balancing the risks of anemia and red blood cell transfusion-associated adverse effects is challenging in neurocritical settings.

Methods

We searched the Cochrane Central Register of Controlled Trials (CENTRAL), Embase, and MEDLINE (PubMed) from inception to January 31, 2024. We included all randomized controlled trials (RCTs) assessing liberal versus restrictive RBC transfusion str

SUBMITTER: Yu Y 

PROVIDER: S-EPMC10949741 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature