Association of GDF15 levels with body mass index and endocrine status in β-thalassaemia.

ABSTRACT:

Objective

GDF15 has emerged as a stress-induced hormone, acting on the brain to reduce food intake and body weight while affecting neuroendocrine function. Very high GDF15 levels are found in thalassaemia, where growth, energy balance and neuroendocrine function are impaired. We examined the relationships between GDF15 and anthropometric measures and endocrine status in β-thalassaemia.

Design

Cross sectional study.

Patients

All β-thalassaemia patients attending the thalassaemia unit of Colombo North Teaching Hospital for blood transfusions.

Measurements

Anthropometric data, appetite scores, circulating GDF15, IGF, thyroid and reproductive hormone levels in 103 β-thalassaemia patients were obtained.

Results

GDF15 levels were markedly elevated in thalassae

SUBMITTER: Karusheva Y 

PROVIDER: S-EPMC10952638 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature