The postprandial secretion of peptide YY_1-36 and _3-36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy.

ABSTRACT:

Objectives

Peptide tyrosine tyrosine (PYY) exists as two species, PYY_1-36 and PYY_3-36 , with distinct effects on insulin secretion and appetite regulation. The detailed effects of bariatric surgery on PYY_1-36 and PYY_3-36 secretion are not known as previous studies have used nonspecific immunoassays to measure total PYY. Our objective was to characterize the effect of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) on fasting and postprandial PYY_1-36 and PYY_3-36 secretion using a newly developed liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay.

Design and subjects

Observational study in 10 healthy nonobese volunteers and 30 participants with obesity who underwent RYGB (n = 24) or SG (

SUBMITTER: Kowalka AM 

PROVIDER: S-EPMC10952770 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature