Bone metastasis in non-small-cell lung cancer: genomic characterization and exploration of potential targets.

ABSTRACT:

Background

Bone metastasis (BM) seriously affects the quality of life and reduces the survival time of patients with non-small-cell lung cancer (NSCLC). The genomic characteristics and potential targets of BMs are yet to be fully explored.

Objective

To explore the genetic characteristics and potential targets of BM in NSCLC.

Design

In all, 83 patients with NSCLC were retrospectively selected in this study. Genomic characterization of BMs was explored with the analysis of NGS results from primary tumors and BMs in 6 patients, then combined with NGS results of lung tumors in 16 patients with initial recurrence in bone to analyze mutations potentially associated with BMs, and finally, the correlation was further validated in 61 postoperative patients.

Methods

The

SUBMITTER: Gong J 

PROVIDER: S-EPMC10953105 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature