Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology.

ABSTRACT: Osteoarthritis (OA) is a multifactorial degenerative joint disease of which the underlying mechanisms are yet to be fully understood. At the molecular level, multiple factors including altered signaling pathways, epigenetics, metabolic imbalance, extracellular matrix degradation, production of matrix metalloproteinases, and inflammatory cytokines, are known to play a detrimental role in OA. However, these factors do not initiate OA, but are mediators or consequences of the disease, while many other factors causing the etiology of OA are still unknown. Here, it is revealed that microenvironmental osmolarity can induce and reverse osteoarthritis-related behavior of chondrocytes via altered intracellular molecular crowding, which represents a previously unknown mechanism underlying OA pathoph

SUBMITTER: Govindaraj K 

PROVIDER: S-EPMC10953583 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature