Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis.

ABSTRACT: Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in 3 main networks: the default mode network (DMN), central executive network, and the salience network (SN). The interrelation and possible mechanisms of these changes are less well understood in chronic pain. Based on emerging evidence of its role to drive switches between network states, the right anterior insula (rAI, an SN hub) may play a dominant role in network connectivity changes underpinning chronic pain. To test this hypothesis, we used seed-based resting-state FC analysis including dynamic and effective connectivity metrics in 25 people with chronic osteoarthritis (OA) pain and 19 matched healthy volunteers. Compared wi

SUBMITTER: Cottam WJ 

PROVIDER: S-EPMC5916486 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature