Linking sarcopenia, brain structure and cognitive performance: a large-scale UK Biobank study.

ABSTRACT: Sarcopenia refers to age-related loss of muscle mass and function and is related to impaired somatic and brain health, including cognitive decline and Alzheimer's disease. However, the relationships between sarcopenia, brain structure and cognition are poorly understood. Here, we investigate the associations between sarcopenic traits, brain structure and cognitive performance. We included 33 709 UK Biobank participants (54.2% female; age range 44-82 years) with structural and diffusion magnetic resonance imaging, thigh muscle fat infiltration (n = 30 561) from whole-body magnetic resonance imaging (muscle quality indicator) and general cognitive performance as indicated by the first principal component of a principal component analysis across multiple cognitive tests (n = 22

SUBMITTER: Gurholt TP 

PROVIDER: S-EPMC10953622 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature