Age-restricted functional and developmental differences of neonatal platelets.

ABSTRACT:

Background

Developmental ontogeny of neonatal thrombopoiesis retains characteristics that are distinct from adults although molecular mechanisms remain unestablished.

Methods

We applied multiparameter quantitative platelet responses with integrated ribosome profiling/transcriptomic studies to better define gene/pathway perturbations regulating the neonatal-to-adult transition. A bioinformatics pipeline was developed to identify stable, neonatal-restricted platelet biomarkers for clinical application.

Results

Cord blood (CB) platelets retained the capacity for linear agonist-receptor coupling linked to phosphatidylserine (PS) exposure and α-granule release, although a restricted block in cross-agonist activation pathways was evident. Functional immaturity of synergisti

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10953828 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature