Stereochemical Heterogeneity Analysis of Polylactides by Multidimensional Liquid Chromatography.

ABSTRACT: A new and robust high-performance liquid chromatography (HPLC) method that separates poly(lactic acid) (PLA) according to its stereochemical composition is presented. Using this method, poly(l-lactide) incorporating trace amounts of meso-lactide resulting from the racemization is separated from the pristine polymer. To prove this aspect in more detail, a representative poly(l-lactic acid) standard, assumed to be highly homogeneous, was separated using this method. The result showed that this was not the case as a fraction incorporating meso-lactide due to racemization occurring during the synthesis is separated. Employing two-dimensional liquid chromatography (2D-LC), the molar mass differences of the separated species were investigated, and fractions with similar molecular s

SUBMITTER: Eselem Bungu PS 

PROVIDER: S-EPMC10955512 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature