Antidiabetics, statins and the risk of amyotrophic lateral sclerosis.

ABSTRACT:

Background

Medications that are used for treatment of metabolic disorders have been suggested to be associated with the development of amyotrophic lateral sclerosis (ALS).

Methods

To examine the associations of antidiabetics and statins with the subsequent risk of ALS we conducted a population-based nested case-control study of 2475 Swedish residents diagnosed with ALS during July 2006 to December 2013 and 12 375 population controls (five for each ALS case). We extracted information on filled prescriptions of antidiabetics and statins for both cases and controls from the Swedish Prescribed Drug Register during the years before ALS diagnosis. Conditional logistic regression was used to calculate odds ratios (ORs) for the associations of these medications with ALS risk.

Res

SUBMITTER: Mariosa D 

PROVIDER: S-EPMC10957794 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature