Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants.

ABSTRACT:

Background

Astroviral infections commonly cause acute nonbacterial gastroenteritis in children globally. However, these infections often go undiagnosed outside of research settings. There is no treatment available for astrovirus, and Astroviridae strain diversity presents a challenge to potential vaccine development.

Methods

To address our hypothesis that host genetic risk factors are associated with astrovirus disease susceptibility, we performed a genome-wide association study of astrovirus infection in the first year of life from children enrolled in 2 Bangladeshi birth cohorts.

Results

We identified a novel region on chromosome 1 near the loricrin gene (LOR) associated with astrovirus diarrheal infection (rs75437404; meta-analysis P = 8.82 × 10^-

SUBMITTER: Chen L 

PROVIDER: S-EPMC10960603 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature