Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk.

ABSTRACT: In this study, two intramammary infusions of cefquinome sulfate were investigated for pharmacokinetics and bioavailability. Twelve lactating cows for each group were administered an effective dose of 75 mg/gland for cefquinome, with milk samples collected at various time intervals. The concentrations of cefquinome in milk at different times were determined by the UPLC-MS/MS method. Analyses of noncompartmental pharmacokinetics were conducted on the concentration of cefquinome in milk. Mean pharmacokinetic parameters of group A and group B following intramammary administration were as follows: AUC_last 300558.57 ± 25052.78 ng/mL and 266551.3 ± 50654.85 ng/mL, C_max 51786.35 ± 11948.4 ng/mL and 59763.7 ± 8403.2 ng/mL, T_1/2 5.69 ± 0.62 h and 5.25 ± 1.62 h, MRT 7

SUBMITTER: Li S 

PROVIDER: S-EPMC10962211 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature