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Emergence of complex oscillatory dynamics in the neuronal networks with long activity time of inhibitory synapses.

ABSTRACT: The brain displays complex dynamics, including collective oscillations, and extensive research has been conducted to understand their generation. However, our understanding of how biological constraints influence these oscillations is incomplete. This study investigates the essential properties of neuronal networks needed to generate oscillations resembling those in the brain. A simple discrete-time model of interconnected excitable elements is developed, capable of closely resembling the complex oscillations observed in biological neural networks. In the model, synaptic connections remain active for a duration exceeding individual neuron activity. We show that the inhibitory synapses must exhibit longer activity than excitatory synapses to produce a diverse range of the dynamical states, including biologically plausible oscillations. Upon meeting this condition, the transition between different dynamical states can be controlled by external stochastic input to the neurons. The study provides a comprehensive explanation for the emergence of distinct dynamical states in neural networks based on specific parameters.

SUBMITTER: Khanjanianpak M

PROVIDER: S-EPMC10963234 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Emergence of complex oscillatory dynamics in the neuronal networks with long activity time of inhibitory synapses.

Khanjanianpak Mozhgan M Azimi-Tafreshi Nahid N Valizadeh Alireza A

iScience 20240304 4

The brain displays complex dynamics, including collective oscillations, and extensive research has been conducted to understand their generation. However, our understanding of how biological constraints influence these oscillations is incomplete. This study investigates the essential properties of neuronal networks needed to generate oscillations resembling those in the brain. A simple discrete-time model of interconnected excitable elements is developed, capable of closely resembling the comple ...[more]

PMID: 38532887

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Project description:Recent experimental data from the rodent cerebral cortex and olfactory bulb indicate that specific connectivity motifs are correlated with short-term dynamics of excitatory synaptic transmission. It was observed that neurons with short-term facilitating synapses form predominantly reciprocal pairwise connections, while neurons with short-term depressing synapses form predominantly unidirectional pairwise connections. The cause of these structural differences in excitatory synaptic microcircuits is unknown. We show that these connectivity motifs emerge in networks of model neurons, from the interactions between short-term synaptic dynamics (SD) and long-term spike-timing dependent plasticity (STDP). While the impact of STDP on SD was shown in simultaneous neuronal pair recordings in vitro, the mutual interactions between STDP and SD in large networks are still the subject of intense research. Our approach combines an SD phenomenological model with an STDP model that faithfully captures long-term plasticity dependence on both spike times and frequency. As a proof of concept, we first simulate and analyze recurrent networks of spiking neurons with random initial connection efficacies and where synapses are either all short-term facilitating or all depressing. For identical external inputs to the network, and as a direct consequence of internally generated activity, we find that networks with depressing synapses evolve unidirectional connectivity motifs, while networks with facilitating synapses evolve reciprocal connectivity motifs. We then show that the same results hold for heterogeneous networks, including both facilitating and depressing synapses. This does not contradict a recent theory that proposes that motifs are shaped by external inputs, but rather complements it by examining the role of both the external inputs and the internally generated network activity. Our study highlights the conditions under which SD-STDP might explain the correlation between facilitation and reciprocal connectivity motifs, as well as between depression and unidirectional motifs.

Dataset Information

Emergence of complex oscillatory dynamics in the neuronal networks with long activity time of inhibitory synapses.

Publications

Emergence of complex oscillatory dynamics in the neuronal networks with long activity time of inhibitory synapses.

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