ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study.

ABSTRACT:

Background

It has been reported that the risk of Alzheimer's disease (AD) could be predicted by the Australian National University Alzheimer Disease Risk Index (ANU-ADRI) scores. However, among non-demented Chinese adults, the correlations of ANU-ADRI scores with cerebrospinal fluid (CSF) core biomarkers and cognition remain unclear.

Methods

Individuals from the Chinese Alzheimer's Biomarker and LifestyLE (CABLE) study were grouped into three groups (low/intermediate/high risk groups) based on their ANU-ADRI scores. The multiple linear regression models were conducted to investigate the correlations of ANU-ADRI scores with several biomarkers of AD pathology. Mediation model and structural equation model (SEM) were conducted to investigate the mediators of the correlation bet

SUBMITTER: Yin S 

PROVIDER: S-EPMC10964631 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature