Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution.

ABSTRACT:

Summary

Heme (iron protoporphyrin IX, FePPIX) is the main source of iron and PPIX for host-associated pathogenic bacteria, including members of the Bacteroidota (formerly Bacteroidetes) phylum. Porphyromonas gingivalis, a keystone oral pathogen, uses a unique heme uptake (Hmu) system, comprising a hemophore-like protein, designated as the first member of the novel HmuY family. Compared to classical, secreted hemophores utilized by Gram-negative bacteria or near-iron transporter domain-based hemophores utilized by Gram-positive bacteria, the HmuY family comprises structurally similar proteins that have undergone diversification during evolution. The best characterized are P. gingivalis HmuY and its homologs from Tannerella forsythia (Tfo), Prevotella intermed

SUBMITTER: Olczak T 

PROVIDER: S-EPMC10966948 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature