Evidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case-control study.

ABSTRACT:

Background

Neuroinflammation and maladaptive neuroplasticity play pivotal roles in migraine (MIG), trigeminal autonomic cephalalgias (TAC), and complex regional pain syndrome (CRPS). Notably, CRPS shares connections with calcitonin gene-related peptide (CGRP) in its pathophysiology. This study aims to assess if the documented links between CRPS and MIG/TAC in literature align with clinical phenotypes and disease progressions. This assessment may bolster the hypothesis of shared pathophysiological mechanisms.

Methods

Patients with CRPS (n = 184) and an age-/gender-matched control group with trauma but without CRPS (n = 148) participated in this case-control study. Participant answered well-established questionnaires for the definition of CRPS symptoms, any headache complaints

SUBMITTER: Wiemann M 

PROVIDER: S-EPMC10972976 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature