Dataset Information
Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes.
Ontology highlight
ABSTRACT: Objectives
Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; it arises from tissue-resident memory T-cells (TRM). In the present study, we investigated potential functional genetic variations that may predispose MF development.Methods
A case-control study was conducted using whole-exome sequencing, with a focus on genes that are essential to TRM function.Results
We included 21 patients and 19 healthy subjects in the study. Single nucleotide polymorphisms in the following genes were significantly more common in patients than in healthy subjects: GZMB, HLA-DRB1, CD103, and NOTCH1. Moreover, the number of patients carrying single nucleotide polymorphisms in LAG3, NR4A2, and CD26L was significantly greater in the patient group than in the control group.Conclusions
The presence of genetic variations in one or more TRM functional gene may predispose patients to develop MF. Further studies involving a larger patient population and a comparative analysis of protein expression will be necessary to validate these findings.
SUBMITTER: Almaani N
PROVIDER: S-EPMC10981233 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Publications
Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes.
The Journal of international medical research 20240301 3
<h4>Objectives</h4>Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; it arises from tissue-resident memory T-cells (T<sub>RM</sub>). In the present study, we investigated potential functional genetic variations that may predispose MF development.<h4>Methods</h4>A case-control study was conducted using whole-exome sequencing, with a focus on genes that are essential to T<sub>RM</sub> function.<h4>Results</h4>We included 21 patients and 19 healthy subjects in the study. Single n ...[more]
