Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes.

ABSTRACT:

Objectives

Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; it arises from tissue-resident memory T-cells (T_RM). In the present study, we investigated potential functional genetic variations that may predispose MF development.

Methods

A case-control study was conducted using whole-exome sequencing, with a focus on genes that are essential to T_RM function.

Results

We included 21 patients and 19 healthy subjects in the study. Single nucleotide polymorphisms in the following genes were significantly more common in patients than in healthy subjects: GZMB, HLA-DRB1, CD103, and NOTCH1. Moreover, the number of patients carrying single nucleotide polymorphisms in LAG3, NR4A2, and CD26L

SUBMITTER: Almaani N 

PROVIDER: S-EPMC10981233 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature