Dataset Information

A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases.

ABSTRACT:

Background and aims

Experiencing a traumatic event may lead to Posttraumatic Stress Disorder (PTSD), including symptoms such as flashbacks and hyperarousal. Individuals suffering from PTSD are at increased risk of cardiovascular disease (CVD), but it is unclear why. This study assesses shared genetic liability and potential causal pathways between PTSD and CVD.

Methods

We leveraged summary-level data of genome-wide association studies (PTSD: N= 1,222,882; atrial fibrillation (AF): N=482,409; coronary artery disease (CAD): N=1,165,690; hypertension: N=458,554; heart failure (HF): N=977,323). First, we estimated genetic correlations and utilized genomic structural equation modeling to identify a common genetic factor for PTSD and CVD. Next, we assessed biological, behavioural, and psychosocial factors as potential mediators. Finally, we employed multivariable Mendelian randomization to examine causal pathways between PTSD and CVD, incorporating the same potential mediators.

Results

Significant genetic correlations were found between PTSD and CAD, HT, and HF (r_g =0.21-0.32, p≤ 3.08 · 10^-16), but not between PTSD and AF. Insomnia, smoking, alcohol dependence, waist-to-hip ratio, and inflammation (IL6, C-reactive protein) partly mediated these associations. Mendelian randomization indicated that PTSD causally increases CAD (IVW OR=1.53, 95% CIs=1.19-1.96, p=0.001), HF (OR=1.44, CIs=1.08-1.92, p=0.012), and to a lesser degree hypertension (OR=1.25, CIs=1.05-1.49, p=0.012). While insomnia, smoking, alcohol, and inflammation were important mediators, independent causal effects also remained.

Conclusions

In addition to shared genetic liability between PTSD and CVD, we present strong evidence for causal effects of PTSD on CVD. Crucially, we implicate specific lifestyle and biological mediators (insomnia, substance use, inflammation) which has important implications for interventions to prevent CVD in PTSD patients.

SUBMITTER: Lukas E

PROVIDER: S-EPMC10984043 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases.

Lukas Eva E Veeneman Rada R RR Smit Dirk Ja DJ Vermeulen Jentien M JM Pathak Gita A GA Polimanti Renato R Verweij Karin Jh KJ Treur Jorien L JL

medRxiv : the preprint server for health sciences 20240322

<h4>Background and aims</h4>Experiencing a traumatic event may lead to Posttraumatic Stress Disorder (PTSD), including symptoms such as flashbacks and hyperarousal. Individuals suffering from PTSD are at increased risk of cardiovascular disease (CVD), but it is unclear why. This study assesses shared genetic liability and potential causal pathways between PTSD and CVD.<h4>Methods</h4>We leveraged summary-level data of genome-wide association studies (PTSD: N= 1,222,882; atrial fibrillation (AF): ...[more]

PMID: 38562880

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Dataset Information

A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases.

Background and aims

Methods

Results

Conclusions

Publications

A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases.

Similar Datasets

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