Obesity-related indicators and tuberculosis: A Mendelian randomization study.

ABSTRACT:

Purpose

Obesity is a strong risk factor for many diseases, with controversy regarding the cause(s) of tuberculosis (TB) reflected by contradictory findings. Therefore, a larger sample population is required to determine the relationship between obesity and TB, which may further inform treatment.

Methods

Obesity-related indicators and TB mutation data were obtained from a genome-wide association study database, while representative instrumental variables (IVs) were obtained by screening and merging. Causal relationships between exposure factors and outcomes were determined using two-sample Mendelian randomization (MR) analysis. Three tests were used to determine the representativeness and stability of the IVs, supported by sensitivity analysis.

Results

Initially, 191 s

SUBMITTER: Cai N 

PROVIDER: S-EPMC10984409 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature