Plasma biomarkers of Alzheimer's disease and related dementias in American Indians: The Strong Heart Study.

ABSTRACT:

Introduction

Identification of Alzheimer's disease (AD) needs inexpensive, noninvasive biomarkers, with validation in all populations.

Methods

We collected plasma markers in older American Indian individuals: phosphorylated-tau181 (pTau181); amyloid-beta (Aβ) 40,42; glial fibrillary acidic protein (GFAP); and neurofilament light chain (NfL). Plasma markers were analyzed for discriminant properties with cognitive status and etiology using receiver operating characteristic (ROC) analysis.

Results

PTau181, GFAP, NfL plasma values were significantly associated with cognition, but Aβ were not. Discriminant performance was moderate for individual markers, with pTau181, GFAP, NfL performing best, but an empirically selected panel of markers (age, sex, education, pTau181, GFA

SUBMITTER: Suchy-Dicey AM 

PROVIDER: S-EPMC10984473 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature