Immunization with a peptide mimicking lipoteichoic acid induces memory B cells in BALB/c mice.

ABSTRACT:

Background

There is an urgent clinical need for developing novel immunoprophylaxis and immunotherapy strategies against Staphylococcus aureus (S. aureus). In our previous work, immunization with a tetra-branched multiple antigenic peptide, named MAP2-3 that mimics lipoteichoic acid, a cell wall component of S. aureus, successfully induced a humoral immune response and protected BALB/c mice against S. aureus systemic infection. In this study, we further investigated whether vaccination with MAP2-3 can elicit immunologic memory.

Methods

BALB/c mice were immunized with MAP2-3 five times. After one month of the last vaccination, mice were challenged with heat-killed S. aureus via intraperitoneal injection. After a 7-day inoculation, the percentage of plasma cells, memory B cells

SUBMITTER: Yi XY 

PROVIDER: S-EPMC10986077 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature