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Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease.


ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) affecting 334 million people in the world remains a major cause of morbidity and mortality. Proper diagnosis of COPD is still a challenge and largely solely based on spirometric criteria. We aimed to investigate the potential of nitrosative/oxidative stress and related metabolic biomarkers in exhaled breath condensate (EBC) to discriminate COPD patients.

Methods

Three hundred three participants were randomly selected from a 15,000-transit worker cohort within the Respiratory disease Occupational Biomonitoring Collaborative Project (ROBoCoP). COPD was defined using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria as post-bronchodilator ratio of Forced Expiratory Volume in 1st second to Forced Vital Capacity < 0.7 in spirometry validated by an experienced pulmonologist. Discriminative power of biomarker profiles in EBC was analyzed using linear discriminant analyses.

Results

Amongst 300 participants with validated spirometry, 50.3% were female, 52.3 years old in average, 36.0% were current smokers, 12.7% ex-smokers with mean tobacco exposure of 15.4 pack-years. Twenty-one participants (7.0%) were diagnosed as COPD, including 19 new diagnoses, 12 of which with a mild COPD stage (GOLD 1). Amongst 8 biomarkers measured in EBC, combination of 2 biomarkers, Lactate and Malondialdehyde (MDA) significantly discriminated COPD subjects from non-COPD, with a 71%-accuracy, area under the receiver curve of 0.78 (p-value < 0.001), and a negative predictive value of 96%.

Conclusions

These findings support the potential of biomarkers in EBC, in particular lactate and MDA, to discriminate COPD patients even at a mild or moderate stage. These EBC biomarkers present a non-invasive and drugless technique, which can improve COPD diagnosis in the future.

SUBMITTER: Freund R 

PROVIDER: S-EPMC10993619 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease.

Freund Romain R   Sauvain Jean-Jacques JJ   Suarez Guillaume G   Wild Pascal P   Charreau Thomas T   Debatisse Amélie A   Sakthithasan Kirushanthi K   Jouannique Valérie V   Pralong Jacques A JA   Guseva Canu Irina I  

Journal of occupational medicine and toxicology (London, England) 20240404 1


<h4>Background</h4>Chronic obstructive pulmonary disease (COPD) affecting 334 million people in the world remains a major cause of morbidity and mortality. Proper diagnosis of COPD is still a challenge and largely solely based on spirometric criteria. We aimed to investigate the potential of nitrosative/oxidative stress and related metabolic biomarkers in exhaled breath condensate (EBC) to discriminate COPD patients.<h4>Methods</h4>Three hundred three participants were randomly selected from a 1  ...[more]

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