Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8⁺ T cells in murine models of inflammation.

ABSTRACT: The differentiation of naive CD8⁺ T cells into effector cells is important for establishing immunity. However, the effect of heterogeneous naive CD8⁺ T cell populations is not fully understood. Here, we demonstrate that steady-state naive CD8⁺ T cells are composed of functionally heterogeneous subpopulations that differ in their ability to differentiate into type 17 cytotoxic effector cells (Tc17) in a context of murine inflammatory disease models, such as inflammatory bowel disease and graft-versus-host disease. The differential ability of Tc17 differentiation is not related to T-cell receptor (TCR) diversity and antigen specificity but is inversely correlated with self-reactivity acquired during development. Mechanistically, this phenomenon is linked to d

SUBMITTER: Lee GW 

PROVIDER: S-EPMC10994929 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature