Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections.

ABSTRACT: Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8⁺ T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a

SUBMITTER: Paprckova D 

PROVIDER: S-EPMC9582129 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature