Universal signatures of transposable element compartmentalization across eukaryotic genomes.

ABSTRACT: The evolutionary mechanisms that drive the emergence of genome architecture remain poorly understood but can now be assessed with unprecedented power due to the massive accumulation of genome assemblies spanning phylogenetic diversity^1,2. Transposable elements (TEs) are a rich source of large-effect mutations since they directly and indirectly drive genomic structural variation and changes in gene expression³. Here, we demonstrate universal patterns of TE compartmentalization across eukaryotic genomes spanning ~1.7 billion years of evolution, in which TEs colocalize with gene families under strong predicted selective pressure for dynamic evolution and involved in specific functions. For non-pathogenic species these genes represent families involved in defense, sensory

SUBMITTER: Gozashti L 

PROVIDER: S-EPMC10996525 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature