Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment.

ABSTRACT: The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival. Leveraging two cohorts of 3703 patients, we first perform a genome-wide survival association analysis to develop eight candidate PPSs. Further using an independent cohort with 470 patients, we identify the 287 variants-derived PPS (i.e., PPS₂₈₇) achieving an optimal prediction performance [hazard ratio (HR) per SD = 1.99, P = 1.76 × 10^-8], accompanied by additional tests in two external cohorts, with HRs per SD of 1.90 (P = 3.21 × 10^-14; 543 patients) and 1.80 (P = 1.11 × 10^-9; 713 patients). Notably, the detrime

SUBMITTER: Xin J 

PROVIDER: S-EPMC11002003 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature