Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS.

ABSTRACT:

Objective

To establish if induced current direction across the motor cortex alters the sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical inhibition (SICI) as an ALS biomarker.

Methods

Threshold tracking-TMS was undertaken in 35 people with ALS and 39 controls. Using a coil orientation which induces posterior-anterior (PA)-directed current across the motor cortex, SICI (1 ms and 3 ms interstimulus intervals) and intracortical facilitation (ICF, 10 ms interstimulus interval) were recorded. SICI_3ms was also recorded using a coil orientation which induces anterior-posterior (AP)-directed current across the motor cortex.

Results

At group level, SICI_3ms-PA (AUROC = 0.7), SICI_3ms-AP (AUROC = 0.8) and S

SUBMITTER: McMackin R 

PROVIDER: S-EPMC11002888 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature