Dataset Information

The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review.

ABSTRACT:

Background

The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies.

Methods

A systematic literature search was performed to identify published full texts describing active monitoring of adult cohorts with incidental and untreated intracranial meningioma (PubMed, EMBASE, MEDLINE, and CINAHL via EBSCO, completed January 24, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were de-duplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the "Core Outcome Measures in Effectiveness Trials" (COMET) initiative.

Results

Thirty-three published articles and 1 ongoing study were included describing 32 unique studies: study designs were retrospective n = 27 and prospective n = 5. In total, 268 verbatim outcomes were reported, of which 77 were defined. Following de-duplication, 178 unique verbatim outcomes remained and were grouped into 53 standardized outcome terms. These were classified using the COMET taxonomy into 9 outcome domains and 3 core areas.

Conclusions

Outcome measurement across observational studies of incidental and untreated intracranial meningioma is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a Core Outcome Set for use in future observational studies.

SUBMITTER: Millward CP

PROVIDER: S-EPMC11003528 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature

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Publications

The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review.

Millward Christopher P CP Islim Abdurrahman I AI Armstrong Terri S TS Barrington Heather H Bell Sabrina S Brodbelt Andrew R AR Bulbeck Helen H Dirven Linda L Grundy Paul L PL Javadpour Mohsen M Keshwara Sumirat M SM Koszdin Shelli D SD Marson Anthony G AG McDermott Michael W MW Meling Torstein R TR Oliver Kathy K Plaha Puneet P Preusser Matthias M Santarius Thomas T Srikandarajah Nisaharan N Taphoorn Martin J B MJB Turner Carole C Watts Colin C Weller Michael M Williamson Paula R PR Zadeh Gelareh G Zamanipoor Najafabadi Amir H AH Jenkinson Michael D MD

Neuro-oncology advances 20240101 1

<h4>Background</h4>The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies.<h4>Methods</h4>A systematic literature search was performed to identify published f ...[more]

PMID: 38596715

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Dataset Information

The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review.

Background

Methods

Results

Conclusions

Publications

The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review.

Similar Datasets

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