Dataset Information

A water transfer printing method for contact lenses surface 2D MXene modification to resist bacterial infection and inflammation.

ABSTRACT: Contact lenses (CLs) are prone to adhesion and invasion by pollutants and pathogenic bacteria, leading to infection and inflammatory diseases. However, the functionalization of CL (biological functions such as anti-fouling, antibacterial, and anti-inflammatory) and maintaining its transparency still face great challenges. In this work, as a member of the MXenes family, vanadium carbide (V₂C) is modified onto CL via a water transfer printing method after the formation of a tightly arranged uniform film at the water surface under the action of the Marangoni effect. The coating interface is stable owing to the electrostatic forces. The V₂C-modified CL (V₂C@CL) maintains optical clarity while providing good biocompatibility, strong antioxidant properties, and anti-inflammatory activities. In vitro antibacterial experiments indicate that V₂C@CL shows excellent performance in bacterial anti-adhesion, sterilization, and anti-biofilm formation. Last, V₂C@CL displays notable advantages of bacteria elimination and inflammation removal in infectious keratitis treatment.

SUBMITTER: Guo H

PROVIDER: S-EPMC11006211 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A water transfer printing method for contact lenses surface 2D MXene modification to resist bacterial infection and inflammation.

Guo Hanwen H Chu Xiaoying X Guo Yishun Y Yang Jianhua J Jin Yingying Y Zhou Liyang L Peng Yaou Y Wang Qingying Q Lu Fan F Wang Bailiang B

Science advances 20240410 15

Contact lenses (CLs) are prone to adhesion and invasion by pollutants and pathogenic bacteria, leading to infection and inflammatory diseases. However, the functionalization of CL (biological functions such as anti-fouling, antibacterial, and anti-inflammatory) and maintaining its transparency still face great challenges. In this work, as a member of the MXenes family, vanadium carbide (V<sub>2</sub>C) is modified onto CL via a water transfer printing method after the formation of a tightly arra ...[more]

PMID: 38598619

Similar Datasets

Project description:IntroductionSoft contact lens wearers are often prescribed the same lens material and modality for multiple years if patients express satisfaction and no significant problems with lens fit or ocular health are noted upon evaluation. Despite their satisfaction, it is possible that other lenses exist that could provide additional health or convenience benefits and still provide satisfied lens wear experience.MethodsIn this study, wearers of a specific monthly replacement lens brand (comfilcon A) were recruited for an open-label study. The habitual contact lens prescription was optimized for 2 weeks of wear and participants confirmed that they were satisfied with their habitual lenses before being refit with daily disposable lenses (verofilcon A). Participants responded to visual analog scale (VAS) survey about their initial impressions of the lenses. After 2 weeks of lens wear, participants completed a final study visit and completed surveys about lens wear experiences with the daily disposable study lenses.ResultsFifteen male and 15 female participants completed the study. Median (IQR) binocular LogMAR visual acuity was -0.20(0.12), which is equivalent to 10/12.5 Snellen acuity. Initial impression surveys revealed median (interquartile range) of 92.5(22.3) for quality of vision; 95.0(19.3) for comfort; and 91.5(19.3) for satisfaction. At the final visit, median scores for EOD quality of vision was 86.5(24.0); EOD comfort was 84.5(30.3), and EOD dryness 25.5(47.0). Median overall VAS scores were 92.5(16.0) for vision; 88.0(18.3) for comfort, and 17.5(25.8) for dryness. Median satisfaction with the study lenses was scored 9(2.8) on a 1-10 scale.ConclusionsIn this study, satisfied wearers of comfilcon A reusable lens were refit with Verofilcon A daily disposable lenses and showed high satisfaction scores with the new lenses, showing that refitting these patients can allow patients to have lenses with more frequent replacement and maintain satisfaction with daily lens wear.

Dataset Information

A water transfer printing method for contact lenses surface 2D MXene modification to resist bacterial infection and inflammation.

Publications

A water transfer printing method for contact lenses surface 2D MXene modification to resist bacterial infection and inflammation.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets