Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension.

ABSTRACT:

Introduction

Portal hypertension (PH) drives the progression of liver cirrhosis to decompensation and death. Hepatic venous pressure gradient (HVPG) measurement is the standard of PH quantification, and HVPG≥10 mmHg defines clinically significant PH (CSPH). We performed proteomics-based serum profiling to search for a proteomic signature of CSPH in patients with compensated advanced chronic liver disease (cACLD).

Materials and methods

Consecutive patients with histologically confirmed cACLD and results of HVPG measurements were prospectively included. Serum samples were pooled according to the presence/absence of CSPH and analysed by liquid chromatography-mass spectrometry. Gene set enrichment analysis was performed, followed by comprehensive literature review for proteins i

SUBMITTER: Pastrovic F 

PROVIDER: S-EPMC11008873 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature