Dataset Information

Clinical and nutritional correlates of bacterial diarrhoea aetiology in young children: a secondary cross-sectional analysis of the ABCD trial.

ABSTRACT:

Objective

The objective was to assess the association between nutritional and clinical characteristics and quantitative PCR (qPCR)-diagnosis of bacterial diarrhoea in a multicentre cohort of children under 2 years of age with moderate to severe diarrhoea (MSD).

Design

A secondary cross-sectional analysis of baseline data collected from the AntiBiotics for Children with Diarrhoea trial (NCT03130114).

Patients

Children with MSD (defined as >3 loose stools within 24 hours and presenting with at least one of the following: some/severe dehydration, moderate acute malnutrition (MAM) or severe stunting) enrolled in the ABCD trial and collected stool sample.

Study period

June 2017-July 2019.

Interventions

None.

Main outcome measures

Likely bacterial aetiology of diarrhoea. Secondary outcomes included specific diarrhoea aetiology.

Results

A total of 6692 children with MSD had qPCR results available and 28% had likely bacterial diarrhoea aetiology. Compared with children with severe stunting, children with MAM (adjusted OR (aOR) (95% CI) 1.56 (1.18 to 2.08)), some/severe dehydration (aOR (95% CI) 1.66 (1.25 to 2.22)) or both (aOR (95% CI) 2.21 (1.61 to 3.06)), had higher odds of having likely bacterial diarrhoea aetiology. Similar trends were noted for stable toxin-enterotoxigenic Escherichia coli aetiology. Clinical correlates including fever and prolonged duration of diarrhoea were not associated with likely bacterial aetiology; children with more than six stools in the previous 24 hours had higher odds of likely bacterial diarrhoea (aOR (95% CI) 1.20 (1.05 to 1.36)) compared with those with fewer stools.

Conclusion

The presence of MAM, dehydration or high stool frequency may be helpful in identifying children with MSD who might benefit from antibiotics.

SUBMITTER: Somji S

PROVIDER: S-EPMC11015214 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Clinical and nutritional correlates of bacterial diarrhoea aetiology in young children: a secondary cross-sectional analysis of the ABCD trial.

Somji Sarah S Ashorn Per P Manji Karim K Ahmed Tahmeed T Chisti Md M Dhingra Usha U Sazawal Sunil S Singa Benson B Walson Judd L JL Pavlinac Patricia P Bar-Zeev Naor N Houpt Eric E Dube Queen Q Kotloff Karen K Sow Samba S Yousafzai Mohammad Tahir MT Qamar Farah F Bahl Rajiv R De Costa Ayesha A Simon Jonathon J Sudfeld Christopher R CR Duggan Christopher P CP

BMJ paediatrics open 20240411 1

<h4>Objective</h4>The objective was to assess the association between nutritional and clinical characteristics and quantitative PCR (qPCR)-diagnosis of bacterial diarrhoea in a multicentre cohort of children under 2 years of age with moderate to severe diarrhoea (MSD).<h4>Design</h4>A secondary cross-sectional analysis of baseline data collected from the AntiBiotics for Children with Diarrhoea trial (NCT03130114).<h4>Patients</h4>Children with MSD (defined as <u>></u>3 loose stools within 24 hou ...[more]

PMID: 38604769

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Dataset Information

Clinical and nutritional correlates of bacterial diarrhoea aetiology in young children: a secondary cross-sectional analysis of the ABCD trial.

Objective

Design

Patients

Study period

Interventions

Main outcome measures

Results

Conclusion

Publications

Clinical and nutritional correlates of bacterial diarrhoea aetiology in young children: a secondary cross-sectional analysis of the ABCD trial.

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