Risk of depression in persons with Alzheimer's disease: A national cohort study.

ABSTRACT:

Introduction

Depression is a risk factor and possible prodromal symptom of Alzheimer's disease (AD), but little is known about subsequent risk of developing depression in persons with AD.

Methods

National matched cohort study was conducted of all 129,410 persons diagnosed with AD and 390,088 with all-cause dementia during 1998-2017 in Sweden, and 3,900,880 age- and sex-matched controls without dementia, who had no prior depression. Cox regression was used to compute hazard ratios (HRs) for major depression through 2018.

Results

Cumulative incidence of major depression was 13% in persons with AD and 3% in controls. Adjusting for sociodemographic factors and comorbidities, risk of major depression was greater than two-fold higher in women with AD (HR, 2.21; 95% confiden

SUBMITTER: Crump C 

PROVIDER: S-EPMC11016814 | biostudies-literature | 2024 Apr-Jun

REPOSITORIES: biostudies-literature