A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps.

ABSTRACT:

Background

The Cancer Epitope Database and Analysis Resource (CEDAR) is a newly developed repository of cancer epitope data from peer-reviewed publications, which includes epitope-specific T cell, antibody, and MHC ligand assays. Here we focus on prostate cancer as our first cancer category to demonstrate the capabilities of CEDAR, and to shed light on the advances of epitope-related prostate cancer research.

Results

The meta-analysis focused on a subset of data describing epitopes from 8 prostate-specific (PS) antigens. A total of 460 epitopes were associated with these proteins, 187 T cell, 109B cell, and 271 MHC ligand epitopes. The number of epitopes was not correlated with the length of the protein; however, we found a significant positive correlation between the number

SUBMITTER: Foos G 

PROVIDER: S-EPMC11017785 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature