In vitro and in silico docking and molecular dynamic of antimicrobial activities, alpha-glucosidase, and anti-inflammatory activity of compounds from the aerial parts of Mussaenda saigonensis.

ABSTRACT: Twelve compounds were isolated from Mussaenda saigonensis aerial parts through phytochemical analysis and the genus Mussaenda is the first place where the compounds 4-6 and 11-12 have been found. Based on the ability to inhibit NO production in RAW264.7 cells, compound 2 has demonstrated the strongest anti-inflammatory activity in vitro with an IC₅₀ of 7.6 μM, as opposed to L-NMMA's IC₅₀ of 41.3 μM. Compound 12 was found to be the most effective inhibitor of alpha-glucosidase enzyme in vitro, with an IC₅₀ value of 42.4 μM (compared to 168 μM for acarbose). Compounds 1-12 were evaluated in vitro for antimicrobial activity using the paper dish method. Compound 11 demonstrated strong antifungal activity against M. gypseum<

SUBMITTER: Ngoc Mai TT 

PROVIDER: S-EPMC11019407 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature