Self-Reinforced Bimetallic Mito-Jammer for Ca²⁺ Overload-Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization.

ABSTRACT: Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria-mediated cell death. However, the highly adaptive nature and damage-repair capabilities of malignant tumors strongly limit the efficacy of treatments based on a single treatment mode. To address this challenge, a self-reinforced bimetallic Mito-Jammer is developed by incorporating doxorubicin (DOX) and calcium peroxide (CaO₂) into hyaluronic acid (HA) -modified metal-organic frameworks (MOF). After cellular, Mito-Jammer dissociates into CaO₂ and Cu²⁺ in the tumor microenvironment. The exposed CaO₂ further yields hydrogen peroxide (H₂O₂) and Ca²⁺ in a weakly acidic envir

SUBMITTER: Du C 

PROVIDER: S-EPMC11022715 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature