CGRP sensory neurons promote tissue healing via neutrophils and macrophages.

ABSTRACT: The immune system has a critical role in orchestrating tissue healing. As a result, regenerative strategies that control immune components have proved effective^1,2. This is particularly relevant when immune dysregulation that results from conditions such as diabetes or advanced age impairs tissue healing following injury^2,3. Nociceptive sensory neurons have a crucial role as immunoregulators and exert both protective and harmful effects depending on the context^4-12. However, how neuro-immune interactions affect tissue repair and regeneration following acute injury is unclear. Here we show that ablation of the Na_V1.8 nociceptor impairs skin wound repair and muscle regeneration after acute tissue injury. Nociceptor endings grow into injured skin an

SUBMITTER: Lu YZ 

PROVIDER: S-EPMC11023938 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature