Regulatory NK1.1^-CD4⁺NKG2D⁺ subset induced by NKG2DL⁺ cells promotes tumor evasion in mice.

ABSTRACT: Regulatory T cells play critical roles in self-tolerance and tumor evasion. CD4⁺NKG2D⁺ cells with regulatory activity are present in patients with NKG2DL⁺ tumors and juvenile systemic lupus erythematosus. We previously showed that TGF-β-producing CD4⁺NKG2D⁺ T cells are present in pCD86-Rae-1ε transgenic mice. Here, we performed both ex vivo and in vivo studies on pCD86-Rae-1ε transgenic mice and an MC38 tumor-bearing mouse model and show that NK1.1^-CD4⁺NKG2D⁺ T cells have regulatory activity in pCD86-Rae-1ε transgenic mice. Furthermore, this T-cell subset was induced in mice transplanted with NKG2DL⁺ tumor cells and produced TGF-β and FasL, and secreted low amounts of IFN-γ. This T-cell subse

SUBMITTER: Lin Z 

PROVIDER: S-EPMC11028319 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature