Heritability and genetic correlations for sleep apnea, insomnia, and hypersomnia in a large clinical biobank.

ABSTRACT:

Rationale

Comorbid insomnia and sleep apnea is reported to have worse outcomes than either condition alone. The local genetic correlations of these disorders are unknown.

Objectives

To identify local genomic regions with heritability for clinically diagnosed sleep apnea and insomnia, and to identify local genetic correlations between these disorders and/or hypersomnia.

Methods

Fifty thousand two hundred seventeen patients of European ancestry were examined. Global and local heritability and genetic correlations for independent regions were calculated, adjusting for obesity and other covariates.

Results

Sleep apnea and insomnia were significantly globally heritable and had 118 and 168 genetic regions with local heritability p-values <.05, respectively. One regio

SUBMITTER: Cade BE 

PROVIDER: S-EPMC11031312 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature