Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule.

ABSTRACT: Non-invasive assessment of fibrogenic activity, rather than fibrotic scars, could significantly improve the management of fibrotic diseases and the development of anti-fibrotic drugs. This study explores the potential of an Affibody molecule (Z09591) labeled with the Al(18)F-restrained complexing agent (RESCA) method as a tracer for the non-invasive detection of fibrogenic cells. Z09591 was functionalized with the RESCA chelator for direct labeling with [¹⁸F]AlF. In vivo positron emission tomography/magnetic resonance imaging scans on U-87 tumor-bearing mice exhibited high selectivity of the resulting radiotracer, [¹⁸F]AlF-RESCA-Z09591, for platelet-derived growth factor receptor β (PDGFRβ), with minimal non-specific background uptake. Evaluation in a mouse mod

SUBMITTER: Wegrzyniak O 

PROVIDER: S-EPMC11039342 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature