Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma.

ABSTRACT:

Background

Epidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus (HCV) compared to non-infected individuals. However, the genetic links between HCV and these lymphomas remain under-researched.

Methods

Mendelian randomization analysis was employed to explore the association between chronic hepatitis C (CHC) and B-cell lymphomas as well as chronic lymphocytic leukemia (CLL). Approximate Bayes Factor (ABF) localization analysis was conducted to find shared genetic variants that might connect CHC with B-cell lymphomas and chronic lymphocytic leukemia (CLL). Furthermore, The Variant Effect Predictor (VEP) was utilized to annotate the functional effects of the identified genetic variants.

Resu

SUBMITTER: Fu L 

PROVIDER: S-EPMC11040981 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature