Associations Between Depression Symptom Burden and Delirium Risk: A Prospective Cohort Study.

ABSTRACT:

Background and objectives

Delirium and depression are prevalent in aging. There is considerable clinical overlap, including shared symptoms and comorbid conditions, including Alzheimer's disease, functional decline, and mortality. Despite this, the long-term relationship between depression and delirium remains unclear. This study assessed the associations of depression symptom burden and its trajectory with delirium risk in a 12-year prospective study of older hospitalized individuals.

Research design and methods

A total of 319 141 UK Biobank participants between 2006 and 2010 (mean age 58 years [range 37-74, SD = 8], 54% women) reported frequency (0-3) of 4 depressive symptoms (mood, disinterest, tenseness, or lethargy) in the preceding 2 weeks prior to initial asses

SUBMITTER: Gaba A 

PROVIDER: S-EPMC11041407 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature